Atrial Failure: Mechanisms, Diagnosis, and Potential Therapeutic Targets

The normal atrial function includes ventricular systolic storage function, early ventricular diastolic conduit function, and auxiliary pump function in late ventricular diastolic function, which assists in ventricular filling and maintaining cardiac output. Atrial dysfunction can result in or increase cardiac dysfunction, impacting the patient’s quality of life and life expectancy, even in the absence of evident valve or ventricular problems. Atrial failure, which mostly refers to the left atrium, has recently been given new clinical meaning and is being treated as a separate condition [1]. The mechanism, diagnosis, and potential therapeutic targets of atrial failure will be discussed in this article to better comprehend and treat atrial failure in the future.