Structural characterization of two new stereoisomeric furofuran lignans using modern spectroscopic methods and quantum chemical calculation
Journal of Molecular Structure(2024)
摘要
C. arborea Roxb stems yielded two newly isolated compounds callicarbonans A and B (1–2), optically active with specific rotations of [α] 25.0 D-14.0, and [α] 25.0 D+4.8, along with thirteen (3–15) reported compounds. Their structures were characterized by contemporary spectroscopic techniques, encompassing 1D (1H, 13C, DPET) and 2D (HSQC, HMBC, 1H–1H COSY, and ROESY) NMR, HR-ESI-MS, UV, IR, ECD. Their absolute configurations (AC) were confirmed through quantum chemical computations, and Diastereomeric Parameter 4 Plus (DP4+) analysis was utilized to identify their relative configurations. The cytotoxicity of all compounds was assessed against cancer cells. Specifically, diterpenoid 13 showed cytotoxic effects against MDA-MB-231, SW620, and HepG2 cancer cells with IC50 values of 20.34±0.89, 20.17±0.95, and 22.72±0.96 µM, respectively.
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关键词
Callicarpa,furofuran lignan,spectroscopy,quantum chemical calculation,DP4+ probability
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