Mucus and Bronchopulmonary Clearance

Abstract Summary This chapter covers the roles of airway surface liquid (ASL), the mucociliary escalator, and cough reflex in protecting the respiratory tract in health. The injurious result of certain disease processes and the negative impact of endotracheal intubation and mechanical ventilation on bronchopulmonary clearance are also discussed. Numerous mucolytic agents are currently used in clinical practice to combat these deleterious effects. These work by modifying ASL production, secretion, and composition, and may have an effect on the mucociliary escalator. Since there is a paucity of evidence in this area, their effects are extrapolated from their use in other respiratory conditions.