Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus Aureus Clinical Isolates

Shuma Tsuji,Kazuyoshi Gotoh, Tadahiro Manabe,Koji Iio,Shinnosuke Fukushima,Osamu Matsushita,Hideharu Hagiya

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE（2024）

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摘要

We investigated the prevalence and characteristics of Cefazolin inoculum effect (CInE) among clinical MSSA isolates in Japan. Although 35.5% (39 isolates) were positive for the blaZ gene, none met the phenotypic criteria for CInE. Our findings suggested a very low prevalence of CInE among MSSA isolates in our clinical setting.

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关键词

Beta-lactamase,blaZ,Cefazolin,Inoculum effect,Staphylococcus aureus

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