Development and Assessment of a Miniaturized Thermocouple for Precise Temperature Measurement in Biological Tissues and Cells
arxiv(2024)
摘要
This study presents a novel thermocouple instrument designed for precise
temperature monitoring within biological tissues and cells, addressing a
significant gap in biological research. Constructed on a Silicon-On-Insulator
(SOI) substrate, the instrument employs doped silicon and chromium/gold
junctions, achieving a Seebeck coefficient of up to 447 uV/K, rapid response
times, high temperature accuracy, and the necessary durability for tissue
measurements. The cleanroom fabrication process yields a device featuring a
triangular sensing tip. Using Finite Element Analysis (FEA) with COMSOL
Multiphysics, the research delves into the device's thermal time constant
within tissue environments. The device's efficacy in biological settings was
validated by measuring temperatures inside ex-vivo tissue samples. Our
findings, bolstered by FEA COMSOL simulations, confirm the device's robustness
and applicability in biological studies. This advancement in thermocouple
microneedle technology provides biologists with an instrument for accurately
tracking temperature fluctuations in tissues.
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