Abstract 2298 Complete in Vitro Reconstitution of the Apramycin Biosynthetic Pathway Demonstrates Incorporation of a Β-D-sugar Nucleotide

Apramycin is a widely used pseudotrisaccharide aminoglycoside antibiotic composed of 2-deoxystreptamine, an octose, and D-4-amino-4-deoxyglucose. The two sugars are linked by an O-glycosidic bond between the C8' and C1