Dual FGFR-targeting and pH-activable Ruthenium-Peptide Conjugates for targeted therapy of Breast Cancer

João Franco Machado, Marco Sá, Inês Pires, Miguel Tarita da Silva,Fernanda M. Marques,Jaime A. S. Coelho,Filipa Mendes, Maria Fátima Minas da Piedade,Miguel Machuqueiro,María Angeles Jiménez,Maria Helena Garcia,João D. G. Correia,Tânia S. Morais

Dalton Transactions（2024）

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摘要

Dysregulation of Fibroblast Growth Factor Receptors (FGFRs) signaling has been associated with breast cancer, yet employing FGFR-targeted delivery systems to improve the efficacy of cytotoxic agents is still sparsely exploited....

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