Tenascin-C modulates alveolarization in bronchopulmonary dysplasia

Wei Liu, Yu Mao, Qianru Lv,Keyu Lu,Chunyu Yin,Rui Cheng,Mingshun Zhang

Inflammation and Regeneration（2024）

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摘要

Bronchopulmonary dysplasia (BPD) is a chronic lung disease characterized by retarded alveolarization. Tenascin-C (TN-C), an extracellular matrix glycoprotein and soluble molecule, is involved in tissue morphogenesis. In the present study, we demonstrated that the level of TN-C in lung tissues was greater in a mouse model of BPD induced by 85

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关键词

Bronchopulmonary dysplasia,Extracellular matrix,Tenascin-C,Hyperoxia,Epithelial cells,ICAM-1

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