Biomimetic Nanocomposites for Glioma Imaging and Therapy

Glioma, the most common primary brain tumor, is highly invasive and grows rapidly. As such, the survival of glioma patients is relatively short, highlighting the vital importance of timely diagnosis and treatment of glioma. However, the blood brain barrier (BBB) and the non-targeting delivery systems of contrast agents and drugs greatly hinder the effective glioma imaging and therapy. Fortunately, in recent years, investigators have constructed various biomimetic delivery platforms utilizing the exceptional advantages of biomimetic nanocomposites, such as immune evasion, homologous targeting ability, and BBB penetrating ability, to achieve efficient and precise delivery of substances to glioma sites for improved diagnosis and treatment. In this concept, we present the application of these biomimetic nanocomposites in fluorescence imaging (FI), magnetic resonance imaging (MRI), and multi-modal imaging, as well as in chemotherapy, phototherapy, and combined therapy for glioma. Lastly, we provide our perspective on this research field. Biomimetic nanocomposites, camouflaged by cell membranes, exosomes or other bio-membranes, exhibit exceptional characteristics that facilitate efficient and precise delivery of contrast agents or drugs to glioma sites. These biomimetic nanocomposites are promising in glioma imaging and therapy, including fluorescence imaging (FI), magnetic resonance imaging (MRI), and multimodal imaging, as well as chemotherapy, phototherapy, and combined therapy. image