An Overview of Systematic Reviews of Medicinal Plants and Herbal Formulations for the Treatment of Climacteric Symptoms

Introduction Climacteric syndrome, marking the end of a woman's reproductive years, is accompanied by a host of physical and emotional symptoms that significantly impact her quality of life. There is a growing demand for safe and effective complementary treatments due necessity of another treatment options to meet clinical needs and women's choice. This has led to a surge of interest in medicinal plants and herbal formulations, with traditional uses across cultures and emerging scientific evidence suggesting potential benefits. Methods A systematic overview was conducted in 2022 across five electronic databases, adhering to the standards and PRISMA guidelines. Eligibility evaluation and methodological quality assessment of studies were performed by independent reviewers using the AMSTAR2 tool. Results The review identified 51 medicinal plants and herbal formulations in 57 systematic reviews. Soy isoflavones, red clover extract, Hypericum perforatum preparations, black cohosh extract, and Chinese herbal medicine formulations demonstrated potential efficacy in managing climacteric symptoms. Discussion/Conclusions This study underscores the potential of medicinal plants and herbal formulations in managing climacteric syndrome symptoms. Notably, soy isoflavones, red clover extract, and black cohosh extract exhibited promising results. However, the current evidence base is variable, underlining the need for rigorous, well-designed research to substantiate these findings. Additionally, the intriguing results related to the reduction of sexual symptoms by Maca and Tribulus terrestris, and the potential therapeutic benefits of botanicals such as evening primrose, fenugreek, vitex, and cannabis, call for deeper investigation. This comprehensive overview serves to guide future research directions and inform clinical practice in this burgeoning field.