Cocrystallization for Improving Anticancer Activity of Drugs
CRYSTAL RESEARCH AND TECHNOLOGY(2024)
摘要
Cocrystallization can change the physicochemical and pharmacokinetic properties of active pharmaceutical ingredients (API) and improve biological activities. This study focuses on the documented biological activities of APIs in cocrystal form, specifically those with anticancer properties. Additionally, the mechanisms by which these APIs exhibit modified anticancer effects are discussed. Generally, this technique can change anticancer activity through solubilization, enhancing dissolution rate, permeability improvement, stabilization, producing a slow-release form, and retaining transient in solution and interaction with receptors. This study focuses on the documented biological activities of APIs in cocrystal form, specifically those with anticancer properties. Additionally, the mechanisms by which these APIs exhibit modified anticancer effects have been discussed. image
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关键词
cancer,cocrystal,crystal engineering,cytotoxicity,therapeutic effect
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