Homozygous HLA-DQB106:02 combined with T-cell receptor alpha polymorphism results in narcolepsy onset - A familial case report
INTERNATIONAL JOURNAL OF IMMUNOGENETICS(2024)
摘要
Narcolepsy is a life-long neurological disorder with well-established genetic risk factors. Human leukocyte antigen-DQB1*06:02 remains the strongest genetic predeterminant; however, polymorphisms in genes encoding the T-cell receptor alpha chain are also strongly linked. This case report shows the inheritance pathway of these genetic markers contributing to narcolepsy onset in a 17-year-old female.
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关键词
autoimmune,family studies,gene - polymorphism,HLA,immunogenetics
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