Diisatin malonyldihydrazone complexes of high valent oxovanadium and oxozirconium ions for bio-chemical effectiveness and catalytic thiophene oxidation

Bis-tridentate diisatin malonyldihydrazone ligand, H(2)Lhm, was prepared from the condensed reaction of isatin with malonic dihydrazide. Its ligandated coordination features were explored from its reactivity towards VO2+ and ZrO2+ ions forming two novel complexes of dinuclear homoleptic design (VOLhm and ZrOLhm, respectively). Elucidation of their chemical structures was formulated within various available spectroscopic ways, besides EA (the elemental analyses), conductivity measurements, and magnetic characteristics. Their bio-accomplishment was evaluated depending on their inhibited action against the growing ability of some well-known bacteria, fungi, and cancer/normal cells of human. The biological results appointed the employed role of VO2+ or ZrO2+ ion in its chelated complex over the free ligand, H(2)Lhm. Their binding mode with ctDNA (i.e. calf thymus DNA) was examined within the viscometric and spectrophotometric titration. VOLhm and ZrOLhm represented a fascinating role in the inhibition of the current microorganisms and the human cancer-normal strains' growth over H(2)Lhm. VOLhm and ZrOLhm exhibited a notable interaction with ctDNA more than that of their H(2)Lhm ligand. From the values of binding constant (K-b = 16.36 and 14.49 x 10(7) mol(-1) dm(3)) and Gibb's free energy (Delta G(b)(not equal) = -47.21 and -44.16 kJ mol(-1)), VOLhm displayed more bio-action within ctDNA than ZrOLhm and H(2)Lhm, referring to the role of VO2+ ion with high redox potential enhancing the bio-reactivity of VOLhm. The catalytic behavior of VOLhm and ZrOLhm was given within the oxidation of thiophene (as a desulfurization process), homogeneously using H2O2. The oxidation optimization was enhanced depending on the type of O = M4+ ion in its complex catalyst (through 4 h at 30 degrees C with 60% yielding of monooxo-product using VOLhm and 4 h and 40 degrees C with 53% using ZrOLhm).