Synthesis of 1,2,3-Triazolo-Chalcone Rings by Using Meldal-sharpless Click Reactions: A Medicinal Chemistry Approach

Novel 1,2,3-Triazolo-Chalcone derivatives were obtained via interactions between azides and chalcone containing terminal alkyne. Click reactions were valuable methods of preparing these compounds in good purity and yield. Different spectroscopic analyses proved the structures of all new obtained products. Copper (I) catalyst plays an essential role in controlling the direction of the terminal-alkynes interactions. It cancels the chirality property, and the reaction is directed to give triazole as a single product. There is no protection for the formation of alternative isomers. A novel series of chalcones containing two triazole rings could be synthesized straightforwardly. The chalcone core linker with one or two triazole molecules was synthesized easily via Meldal-Sharpless click reaction. Our target products 4a-c and 5a-c were obtained in good to excellent yields and were characterized with different spectroscopic data, including H-1 NMR, C-13 NMR, MS, and elemental microanalyses.