Figure S2 from Multiomic-Based Molecular Landscape of FaDu Xenograft Tumors in Mice after a Combinatorial Treatment with Radiation and an HSP90 Inhibitor Identifies Adaptation-Induced Targets of Resistance and Therapeutic Intervention

Supplemental Figure S2: IPA pathway highlights genes relevant to Organismal Death, Viral Infection and Vasculogenesis for Treatment groups at Week 1 compared to Control Day 1. Significantly altered genes (2-fold change, p < 0.01) are shown. White indicates no significant change, Red indicates upregulation, Blue indicates downregulation. Black arrows indicate genes of interest. Drug+Rad and Drug alone caused significantly more gene up/down regulation than Rad alone. More genes exist in these pathways than are displayed, for ease of visualization only genes which showed significant changes in expression in at least 2 treatment groups are presented. Genes may be relevant to more than one pathway (PLAUR) is relevant to Organismal Death and Vasculogenesis, but to avoid redundancy is shown once.