MRE11 Lactylation: a Linker Between Warburg Effect and DNA Repair

Lysine lactylation is a recently discovered post-translational modification with emerging roles in both physiology and dis-ease.A recent study published in Cell shows that lactate-induced lactylation of the homologous recombination(HR)protein meiotic recombination 11 results in HR hyperactivation and chemoresistance in cancer cells,establishing a previously unrecognized link between cellular metabolism and deoxyribo-nucleic acid(DNA)damage repair and providing new insights into how altered glucose metabolism can impact DNA damage response m cancer.