WCN24-2419 ANGIOTENSIN II TYPE 2 RECEPTOR (AT2R) AGONIST C21 ELICITS A NEPHROPROTECTIVE EFFECT DURING RENAL ISCHEMIA/REPERFUSION BY STABILIZING THE PRIMARY CILIA IN TUBULAR CELLS

AT2R agonist C21 elicits nephroprotective effects in ischemia/reperfusion (IR)-induced acute kidney injury (AKI) by preventing tubular cell damage. IR-induced AKI associates with tubular cell deciliation. Primary cilia are sensory organelles that regulate signaling pathways central for tubular cell survival, whose stability depends on α-tubulin acetylation. Extracellular signal-regulated kinases (ERK) activates Histone-deacetylase 6 (HDAC6), which is the main α-tubulin deacetylase involved in loss of primary cilia stability in epithelial cells.