WCN24-943 CASE REPORT: CHRONIC MYELOMONOCYTIC LEUKEMIA PATIENT DEVELOPED PROGRESSIVE CHRONIC KIDNEY DISEASE CAUSED BY LYSOZYME-INDUCED NEPHROPATHY

Lysozyme-induced nephropathy is a rare kidney manifestation mostly associated with hematologic diseases, especially Chronic Myelomonocytic Leukemia (CMML). This nephropathy is rare, underrecognized and underestimated in this population. Lysozyme is a 15 kDa cationic protein, produced mainly by monocytes and macrophages. The disease pathogenesis is not well understood; however, it is probably related to lysozyme's direct tubular injury after endocytic reabsorption by proximal tubules, leading to ischemic tubular damage.