How an intrinsically disordered regulatory subunit assembles a PP1:eIF2 complex
Cell Reports(2024)
摘要
Fatalska et al.1 use an interdisciplinary strategy to elucidate how an intrinsically disordered regulatory subunit of protein phosphatase 1 binds trimeric eIF2 and positions the phosphatase-substrate complex for dephosphorylation. As validation, they show that a disease mutation abolishes the interaction.
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