Self-reported concussion history is not related to cortical volume in college athletes.

The long-term consequences of concussion are still being uncovered but have been linked to disruptions in cognition and psychological well-being. Previous studies focusing on the association between concussion history and structural changes in the brain have reported inconsistent results. We sought to examine the effect of concussion history on cortical volume with a focus on functional networks. These networks are associated with many of the functions that can be disrupted in those with an extensive concussion history. Collegiate athletes (n=296) in the present study who self-reported concussion history did not report different baseline symptoms and did not exhibit consistent differences in cognitive performance relative to those who reported no concussion history. We found that concussion history was not related to cortical volume at the network or region level, even when we compared participants with two or more concussions to those with no concussion history. We did identify relationships between cortical volume in the visual network and dorsal attention network with cognitive performance. In addition to comparing cortical volume between individuals with and without reported concussion history, we also examined whether cortical volume changes could be observed within individuals from baseline to acutely following concussion. We found that network level cortical volume did not change within subjects from baseline measurement to acutely post-concussion. Together, these results suggest that both self-reported concussion history and acute concussion effects are not associated with changes in cortical volume in young adult athletes. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement Funding for this study was provided by the Great Plains IdeA-CTR (MN) and the UNL Office for Research and Economic Development. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: IRB of the University of Nebraska-Lincoln gave ethical approval for this work. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes Deidentified data from this study are not available in a public archive because participants did not consent to having deidentified data made publicly available. Deidentified data from this study will be made available (as allowable according to institutional IRB standards) by emailing the corresponding author.