Many Roads to a Gene-Environment Interaction
AMERICAN JOURNAL OF HUMAN GENETICS(2024)
摘要
Despite the importance of gene-environment interactions (GxEs) in improving and operationalizing genetic discovery, interpretation of any GxEs that are discovered can be surprisingly difficult. There are many potential biological and statistical explanations for a statistically significant finding and, likewise, it is not always clear what can be claimed based on a null result. A better understanding of the possible underlying mechanisms leading to a detected GxE can help investigators decide which are and which are not relevant to their hypothesis. Here, we provide a detailed explanation of five “phenomena,” or data-generating mechanisms, that can lead to nonzero interaction estimates, as well as a discussion of specific instances in which they might be relevant. We hope that, given this framework, investigators can design more targeted experiments and provide cleaner interpretations of the associated results.
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关键词
Gene Expression
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