Development of a Green Water-Induced Restricted Access Supramolecular Solvent Microextraction Method for Highly Improved Determination of Pesticides with a Wide Range of Polarity in Water Samples and Cereal Flours

A novel green microextraction supramolecular (SUPRA)-based method for simultaneous preconcentration of seven pesticides, acetamiprid, azoxystrobin, bifenthrin, carbendazim, chlorpyrifos, imidacloprid, and tebuconazole, in water samples and cereal flours with further determination by HPLC-DAD was developed. The method uses 113 µL of 1-decanol as amphiphilic extractor and 500 µL of tetrahydrofuran as disperser solvent. To perform the method optimization, a 25 factorial design and Doehlert design combined with Derringer–Suich desirability function and response surface methodology were used. The microextraction of the pesticides was carried out at pH 6.3 in the presence of 5