Interface Potential Induced Natural Antioxidant Mimic System for the Treatment of Alzheimer's Disease

Abstract Although the pathogenesis of Alzheimer's disease (AD) is still unknown, the molecular biology of its pathological phenomena is indeed clear, mainly due to mitochondrial dysfunction and central nervous system inflammation caused by imbalanced antioxidant capacity in nerve cells, as well as subsequent synaptic dysfunction, so antioxidant therapy is still the preferred treatment for AD in clinical practice. However, although antioxidant enzymes have high catalytic efficiency, the substrate spectrum is narrow (just targeting specific types of substrates); Antioxidants have a wider range of effects, but their efficiency is low. Therefore, the antioxidant system in organisms is composed of both antioxidant enzymes and antioxidants, which is also the key to using simulated antioxidant systems for AD treatment. Since the antioxidant defense system in high-grade organisms is composed of both enzymatic and non-enzymatic systems, therefore we synthesized a metal-organic framework (MOF) with superoxide dismutase activity, and then depending on the interface potential effect, curcumin (non-enzymatic antioxidant capacity) was loaded into MOF to construct a synergistic antioxidant AD treatment system. This system demonstrates both good antioxidant activity and efficient β-amyloid plaque scavenging ability, which slowed down the cognitive dysfunction in the brain of AD mice.