Investigation of Hemodynamic Behaviors in the Liver

Precise assessment of perfusion and flow parameters within the liver holds considerable significance and bears broad implications across diverse medical fields. Thus far, distinct functional facets of hepatic activity and blood circulation have been delineated across various vascular scales. A holistic examination of blood flow within this intricate vascular network can furnish a comprehensive comprehension of flow distribution spanning the entirety of the liver. This study innovatively employed a realistic integrated liver model to investigate perfusion. A comprehensive model encompassing the hepatic artery, portal vein, hepatic vein, and parenchyma was constructed, and hemodynamic parameter values were deduced through computational fluid dynamics simulations utilizing pressure boundary condition values. The findings highlighted the heightened vulnerability of downstream vessels and branches across all three vessels, wherein local velocity increases in response to geometrical alterations. Moreover, the outcomes underscored the predominant blood supply allocation to the right lobe of the liver, amplifying its clinical significance for surgical interventions and treatment strategies.