Deep Eutectic System-Based Liquisolid Nanoparticles as Drug Delivery System of Curcumin for In-Vitro Colon Cancer Cells

This study aims to improve curcumin’s solubility and anti-cancer effectiveness by utilizing deep eutectic solvents (DES)-based liquisolid nanoparticles. This study aims to develop mesoporous silica nanoparticles (MSNs) containing curcumin and evaluate their therapeutic efficacy against the HCT 116 human colon cancer cell line. The study focused on developing different DES formulations using Menthol and Capric Acid, evaluating the effectiveness of surfactants such as Labrasol and Tween 80 in enhancing curcumin dissolution, and synthesizing curcumin-loaded MSNs. The stability of nanoparticles in deep eutectic solvents (DES) and their pharmacological impact on colon cancer cells were thoroughly assessed. The solubility of curcumin was significantly enhanced through the use of deep eutectic solvent (DES) formulations, specifically when Tween 80 was employed as a surfactant. The in vitro tests showed that curcumin-loaded MSNs with Tween 80 demonstrated strong anti-cancer activity, as indicated by an IC50 value of around 100 µM. The study effectively shows that DES-based MSNs can greatly improve curcumin’s solubility and anti-cancer effectiveness. Tween 80, as a surfactant, enhances its therapeutic potential, indicating promising prospects for future clinical applications in cancer treatment.