SOX17: escape route from immune destruction in early CRC
Trends in Molecular Medicine(2024)
摘要
In a recent report in Nature, Goto et al. reveal a novel immune-evasion mechanism adopted by early colorectal cancer (CRC) cells that is based on the transcription factor sex determining region Y (SRY)-box transcription factor 17 (SOX17). Leveraging colorectal adenoma and cancer models to perform comprehensive transcriptomic/chromatin analyses, this work shows that SOX17 generates immune-silent leucine-rich repeat-containing G protein-coupled receptor 5– (LGR5–) tumor cells, which suppress interferon gamma (IFNγ) signaling and promote immune escape.
更多查看译文
关键词
colorectal adenoma,colorectal cancer,immune evasion,IFNγ,SOX17
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要