Re-weighting MDS-UPDRS Part II Items for Optimal Sensitivity to Parkinson’s Disease Progression Using Parkinson’s Progression Markers Initiative Natural History Data (P11-3.012)

Samuel Dickson,Basia Rogula, Jordan Dubow, Nick Kozauer,Lauren Powell,Michele Potashman, Kim Crimin,Patrick O’Keefe, Ellen Korol, Madeline Crabtree, Fernanda Nagase,Vladimir Coric,Suzanne Hendrix,Gilbert L’Italien

Neurology（2024）

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Abstract

This work examines how composite scores (CS) of re-weighted combinations of the MDS-UPDRS PART II items can better detect meaningful changes and increase success for efficacious disease-modifying treatments.

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