Exploring Lipid Disturbances and Its Spatial Association with Α-Synuclein Aggregation in MSA Patient Brain Regions Via Desorption Electrospray Ionization Mass Spectrometry Imaging (P5-3.004)

In this study, we assessed the utility of DESI-MSI for the analysis of lipid disturbances in brain tissues related to Multiple system atrophy (MSA) using a straightforward sample preparation method that minimizes tissue damage. Additionally, this study aimed to investigate the spatial distribution of lipids within various brain regions impacted by MSA and determine any potential correlations between lipid distribution and the presence of α-synuclein.