Diabetic Ketoacidosis in Type 1 Diabetes Onset in Latin American Children

Valeria Hirschler, Claudio D. Gonzalez, Gabriela Krochik, Adriana M. Rousos, Maria E. Andres, Francisca Riera, Paola Pinto Ibarcena,Claudia Molinari, Luis F. Palacios Porta,Mariana Prieto,Carolina Martinez Mateu, Consuelo Barcala, Maria A. Arrigo, Jacqueline. Tachetti,Marcela Raggio, Veronica Vacarezza, Maria L. Major,Angela Figueroa Sobrero, Ernesto Bogado, Stella Lopez

Journal of Pediatric Health Care(2024)

引用 0|浏览0
暂无评分
摘要
Objective To describe the patterns of diabetic ketoacidosis (DKA) occurrence in children newly diagnosed with type 1 diabetes (T1DM) across several Latin American pediatric diabetes centers from 2018 to 2022. Methods A retrospective chart review included children under 18 with new-onset T1DM from 30 Latin American pediatric diabetes centers (Argentina, Chile, and Peru) between 30 December 2018 and 30 December 2022. Multiple logistic regression models examined the relationships between age, gender, medical insurance, BMI, and DKA at new-onset T1DM. As far as we know, there are no large studies in Latin American countries exploring the patterns of DKA in new-onset T1DM. Results A total of 2,026 (983 females) children, median age 9.12 (5.8 -11.7) years with new-onset-T1DM were included. Approximately 50% had no medical insurance. Mean glucose values were 467 mg/dL, pH 7.21, bicarbonate 13 mEq/L, HbA1c 11.3%, and BMI 18. The frequency of DKA was 1,229 (60.7%), out of which only 447 (36%) were severe. There was a significant decrease in the frequency of DKA as age increased: 373 (70.2%) in children under 6, 639 (61.6%) in those between 6 and 12, 217 and (47.5%) in those over 12. Children with medical insurance (58.8%) had a significantly lower frequency of DKA than those without (62.7%). The multiple logistic regression models showed that DKA was significantly and inversely associated with age [OR, 0.72 (95% CI 0.60–0.86)], BMI [OR, 0.95 (95% CI 0.92–0.99)], and medical insurance [OR, 0.75 (95% CI 0.60–0.94)] adjusted for sex. Conclusion Latin American children with new-onset T1DM exhibited a substantial occurrence of DKA. Younger ages and the lack of medical insurance were significantly associated with DKA in new-onset T1DM.
更多
查看译文
关键词
Diabetic ketoacidosis,onset type 1 diabetes,Latin American children
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要