Living in High-Poverty Areas is Associated with Reduced Survival in Patients with Thoracoabdominal Aortic Aneurysm

Objectives Studies have demonstrated socioeconomic status, insurance, race, and distance impact clinical outcomes in patients with abdominal aortic aneurysms (AAA). The purpose of this study was to assess if these factors also impact clinical outcomes in patients with thoracoabdominal aortic aneurysms (TAAA). Methods We conducted a retrospective review of patients with TAAAs confirmed by CT imaging between 2009 to 2019 at a single institution. Patients’ zip codes were mapped to American Community Survey Data to obtain geographic poverty rates. We used the standard US Census definition of high-poverty concentration, as >20% of the population living at 100% of the poverty rate. Our primary outcome was overall survival, stratified by whether the patient underwent repair. Results Of 578 patients, 575 had zip code data and were analyzed. In both the non-operative (N=268) and operative (N=307) groups there were no significant differences in age, race, co-morbidities, clinical urgency, surgery utilization, or surgery modality between patients living in high-poverty areas (N=95, 16.4%) versus not. In the non-operative group, patients from high-poverty areas were more likely to have aneurysm due to dissection (37.5 vs. 17.6%, P=0.03). In multivariate analyses, patients from high-poverty zip codes had significantly worse non-operative survival (HR 1.9, 95% 1.1-3.3, P=0.03). In the repair group, high-poverty was also a significant predictor of reduced post-operative survival (HR 1.65, 95% 1-2.63, P=0.04). Adding the Gagne Index, these differences persisted in both groups (non-operative: HR 1.93, 95% 1.01-3.70, P = 0.05; operative: HR 1.62, 95% 1.03-2.56, p = 0.04). In Kaplan-Meier analysis the difference in post-operative survival began approximately 1.5 years after repair. Private insurance was predictive of improved post-operative survival (HR 0.42, 95% 0.18- 0.95, P=0.04) but reduced non-operative survival (HR 2.05, 95% 1.01-4.14, P=0.04). Data were insufficient to determine if race impacted survival discretely from poverty status. These results were found after adjusting for age, race, sex, maximum aortic diameter, coronary artery disease, distance from the hospital, insurance, and active smoking. Interestingly, in multivariate regression, traveling greater than 100 miles was correlated with increased surgery utilization (OR 1.58, 95% 1.08-2.33, P=0.02) and long-term survival (HR 0.61, 95% 0.41-0.92, P=0.02). Conclusions Patients with TAAA living in high-poverty areas had significantly more dissections and suffered a nearly doubled risk of mortality compared to patients living outside such areas. These data suggest that these disparities are attributed to the overall impacts of poverty and highlight the pressing need for research into TAAA disparities.