allofus: An R package to facilitate use of the All of Us Researcher Workbench

Objective We aimed to increase research and training capacity for the All of Us community through an R package designed to reduce barriers to entry to the Researcher Workbench. Materials and Methods We developed the open-source R package allofus, available on the R package repository CRAN. The package provides functions that address common challenges we encountered while working with All of Us Research Program data. We tested the package with standard R unit tests and in real research projects. Results We describe how the package functions allow for an efficient workflow. We demonstrate the package’s utility by creating a cohort of All of Us participants with one year of electronic health record data prior to survey completion and no previous diagnosis of Type 2 diabetes. Discussion Despite the program’s easy-to-use tools like the Cohort Builder, using All of Us data for complex research questions requires a relatively high level of technical expertise. We developed an initial set of functions that solve problems we experienced with our own research and in mentoring student projects. In conjunction with the tutorials provided with the package, these tools can reduce the barrier for entry into the All of Us research community. The package will continue to grow and develop with the All of Us Research Program. Conclusion The allofus R package can help build community research capacity by increasing access to the All of Us Research Program data, the efficiency of its use, and the rigor and reproducibility of the resulting research. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study did not receive any specific funding ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: IRB of Northeastern University waived ethical approval for this work I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All of Us Research Program data are freely available to registered researchers.