Development of a new method for activation of isotope exchange

The in uence of various factors on the e ciency of introducing deuterium into3-(N-pyrrolyl)-propanoylL-histidine and 3-(N-salicyl)-propanoyl-L-histidine has been studied. Heavy water was used as a source of deuterium. It is shown that the content of deuterium atoms in the substance can be increased by pretreating the reaction mixture with deuterium gas. The new approach opens up additional possibilities both for obtaining highly puri ed preparations by introducing hydrogen isotopes into organic compounds, and theoretically for a deeper understanding of the participation in this process of activated deuterium or tritium particles solvated on the carrier and in the pool of the substance.