Tailoring of Novel Morpholine-Sulphonamide Linked Thiazole Moiety As Dual Targeting DHFR/DNA Gyrase Inhibitors: Synthesis, Antimicrobial, Antibiofilm Activities and DFT with Molecular Modelling Studies

Herein, the chemical synthesis of new thiazoles-based benzenesulfonamide-linked morpholine 4a,b–7 via late-stage thiazolation of the corresponding thiosemicarbazone 3 was reported. The skeletal formulas of the new compounds were confirmed by...