0917 Excessive Daytime Sleepiness and Health-related Quality of Life in Adolescent Patients with PCOS

Abstract Introduction Patients with polycystic ovary syndrome (PCOS) have been reported to have an impaired quality of life (QoL). A high prevalence of sleep disorders has also been reported in this group. This study seeks to evaluate the degree of excessive daytime sleepiness and sleep related QoL in adolescent patients with PCOS. Methods Patients seeking treatment at our multidisciplinary PCOS clinic who were evaluated by Sleep Medicine from July 2023 to December 2023 and completed the Epworth Sleepiness Scale for Children and Adolescents (ESS-CHAD) and OSA-18 questionnaire were included in this study. The ESS-CHAD is an 8 question, validated measure of daytime sleepiness in children 12-18. Scores >10 suggest excessive sleepiness. The OSA-18 is an 18-item questionnaire that uses a Likert-type scoring system to collect information about 5 subscales that are elements in QoL: sleep disturbance, physical symptoms, emotional symptoms, daytime function, and caregiver concerns. A summary score is calculated that ranges from 18 (no impact on QoL) to 126 (major negative impact). Scores lower than 60 suggest a mild impact on QoL, scores between 60 and 80 suggest a moderate impact, and scores greater than 80 suggest a large impact. Descriptive statistics include means (SD) and n (%). Results Sixteen subjects, mean age 16.68 years (SD 1.65), mean BMI 41.8 (SD 11.02) met inclusion criteria. Ten (62%) reported excessive daytime sleepiness as assessed by the ESS-CHAD. OSA-18 scores ranged from 23 to 84 with 2/16 (12.5 %) of subjects having a moderate or severe impairment and 14/16 (87.5%) subjects having a mild impairment. Conclusion Among adolescent patients seeking treatment at a multidisciplinary PCOS clinic, the majority reported excessive sleepiness with mild impact on their QoL as assessed by disease specific questionnaires. Future studies will further investigate the contribution of sleep disordered breathing and evaluate the impact of obesity and insulin resistance on excessive sleepiness and health related QOL as measured by ESS-CHAD and OSA-18 scores. Support (if any)