The impact of permanent pacemaker implantation on long-term survival following cardiac surgery; A systematic review and meta-analysis

Objectives The long-term impact of permanent pacemaker (PPM) implantation on survival following cardiac surgery remains ill defined. We aimed to investigate the impact of PPM on survival and explore factors driving outcomes using meta-regression according to the type of surgery. Methods MEDLINE, EMBASE, and CENTRAL were searched through October 2023 to identify studies reporting the long-term outcomes of PPM implantation. The primary outcome was all-cause mortality during follow-up. The secondary outcome was heart failure rehospitalization. The subgroup analysis and meta-regression analysis were performed according to the type of surgery. Results A total of 28 studies met the inclusion criteria. 183,555 patients (n = 6,298; PPM, n = 177,257; no PPM) were analyzed for all-cause mortality, with a weighted median follow-up of 79.7 months. PPM implantation was associated with increased risks of all-cause mortality during follow-up (HR 1.22; 1.08-1.38, P < 0.01) and heart failure rehospitalization (HR 1.24; 1.01-1.52, P = 0.04). Meta-regression demonstrated the adverse impact of PPM was less prominent in patients undergoing mitral or tricuspid valve surgery, while studies with a higher proportion with aortic valve replacement were associated with worse outcomes. Similarly, a higher proportion with atrioventricular block as an indication of PPM was associated with worse survival. Conclusion PPM implantation following cardiac surgery is associated with a higher risk of long-term all-cause mortality and heart failure rehospitalization. This impact is more prominent in patients undergoing aortic valve surgery or atrioventricular block as an indication than those undergoing mitral or tricuspid valve surgery.