Characterization of human skin under tension using terahertz time domain spectroscopy

This paper introduces a spectral analysis method for monitoring the human skin in vivo based on a combination of terahertz time-domain spectroscopy (THz-TDS) and optical coherence tomography (OCT). The method can quantitatively measure the refractive index, thickness and transmission coefficient of epidermis, and the refractive index of dermis in natural, as well as the tension condition of the skin. An optically reflective model for the multilayer structure of the skin is first established. The initial thickness of the epidermis is then measured by OCT as a known quantity for the established model. By fitting the established model to the experimentally obtained THz-TDS signals, the above parameters of the skin can be calibrated. Furthermore, the dependence of these skin parameters on the tension status are investigated. This study provides a means for terahertz technology to measure the skin in vivo. In this study, a combination of terahertz time-domain spectroscopy (THz-TDS) and optical coherence tomography is proposed to monitor the changes in refractive index, epidermal thickness, and transmission coefficient of in vivo skin under different states of tension. This work presents a feasible method for measuring in vivo skin by terahertz (THz) radiation. image