Abstract 16634: Preoperative Biomarkers of Inflammation and Oxidative Stress Predict Early Outcomes and Only Modestly Decline After Left Ventricular Assist Device Implantation: A Prospective Study

Background: Inflammation and oxidative stress play a pivotal role in pathogenesis of heart failure (HF). Left ventricular assist device (LVAD) is a durable option for treatment of advanced HF, however i) trends of inflammatory and oxidative biomarkers over time are unknown and ii) complications such as right ventricular failure (RVF), stroke and renal failure remain high. The aims of this study were to: i) study longitudinal patterns of inflammation and oxidative stress in LVAD pts and ii) create a biomarker score to identify pts at risk for early adverse events. Methods: We prospectively studied 67 pts (166 samples): pre-LVAD n=56; LVAD (1mo; n=45); LVAD (3-6mo; n=39); LVAD (9-12mo; n=18) and LVAD (18mo; n=8). Inflammatory/oxidative biomarkers: adiponectin, C-reactive protein (CRP), endothelin-1(ET1), interleukin-6 (IL6), tumor necrosis factor- α (TNF α), isoprostane(IsoP), soluble (sCD14), trimethylamine N-oxide (TMAO) were measured in blood. Adverse events including death, stroke, RV failure, and renal replacement therapy (RRT) during implant admission were collected. A pre-LVAD biomarker score was calculated accounting for the number of biomarkers greater than median. Composite event was combination of death, stroke, RV failure and RRT. The RV failure and composite event rates were tested against the biomarker score (更多