Abstract 12715: Aortic Arch Width Adds to Coronary Artery Calcium for Prediction of Incident Adverse Cardiovascular Disease Events: The Framingham Heart Study

Introduction: Aortic arch width (AAW) is cross-sectionally associated with multiple cardiovascular disease (CVD) risk factors. We sought to determine whether AAW would add to standard Framingham risk factors (FRF) and coronary artery calcium (CAC) as a predictor of incident adverse CVD events. Methods: AAW, the distance between the centroids of the ascending and descending aorta at the level of main pulmonary artery bifurcation, was measured in 3026 Framingham Offspring and Third Generation cohort members who underwent computed tomography (CT) for CAC assessment over 2002-2005. Upper 90th percentile (P90) limits, based on sex, age and body surface area, were determined from a healthy referent group (no hypertension, diabetes, dyslipidemia, smoking; N=1471). Participants with prevalent CVD (N=119) or missing covariates (N=27) were excluded from further analysis, leaving 2880 who were dichotomized by AAW ≥P90 (high AAW) or 更多