Two new triterpenoid saponins and two new goodyerosides isolated from the whole plant of Tournefortia sibirica

Two new triterpenoid saponins (oleanolic acid 2 beta-hydroxyl-3-O-beta-D-glucuronopyranoside-6'-O-buthyl ester (1) and oleanolic acid 2 beta-hydroxyl-3-O-[beta-D-glucuronopyranosyl-6 '-O-methylester]-28-O-beta-D-glucopyranoside (2)) and two new goodyerosides (4-methylenefuran-2(5H)-one (6 '-O-vanilloyl)-beta-D-glucopyranoside (3), 3-hydroxy-2(5H)-furanone, 4-(6 '-O-vanilloyl)-beta-D-glucopyranoside (4)), together with seven known compounds (5-11) were isolated from the whole plant of Tournefortia sibirica L. The chemical structures of the compounds were determined by spectroscopic analysis (1D and 2D NMR) and HR-ESI-MS. Compounds 1, 6 and 9 showed significant cytotoxicity towards A549, SK-Hep1 and HeLa cells, with IC50 values ranging from 1.68 +/- 0.09 to 6.87 +/- 0.13 mu M.