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Asthma and Cardiovascular Disease: Embracing Disease Heterogeneity is Required

European respiratory journal/˜The œEuropean respiratory journal(2024)

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Abstract
We read with interest the recent original research investigation by Valencia-Hernández et al . [1]. This observational study used two approaches to investigate the association of asthma and coronary heart disease (CHD): medical records and Mendelian randomisation (MR). Their results differ compared to many other prior studies investigating the association of asthma and CHD [2]. We applaud the authors for the thoroughness of the investigation; however, we have identified key methodological considerations in this study which may account for differences in the conclusions, compared to prior studies. Accounting for the heterogeneity of the asthma syndrome is crucial when investigating the systemic manifestations of asthma
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