Evaluating Humoral Immunity Elicited by XBB.1.5 Monovalent COVID-19 Vaccine.

Xammy Huu Nguyenla,Timothy A Bates, Mila Trank-Greene, Mastura Wahedi,Fikadu G Tafesse,Marcel Curlin

Emerging infectious diseases（2024）

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摘要

Because novel SARS-CoV-2 variants continue to emerge, immunogenicity of XBB.1.5 monovalent vaccines against live clinical isolates needs to be evaluated. We report boosting of IgG (2.1×), IgA (1.5×), and total IgG/A/M (1.7×) targeting the spike receptor-binding domain and neutralizing titers against WA1 (2.2×), XBB.1.5 (7.4×), EG.5.1 (10.5×), and JN.1 (4.7×) variants.

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关键词

COVID-19,respiratory infections,severe acute respiratory syndrome coronavirus 2,SARS-CoV-2,SARS,coronavirus disease

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