A highly sensitive electrochemical sensing platform to detect rutin in pharmaceutical and serum samples

In this study, we created a brand-new g-C3N4-MWCNTs/Ag/β-CD-MOF electrode that can be used as a platform for the electrochemical sensing of Rutin (RT). The g-C3N4-MWCNTs/Ag/β-CD-MOF composite was synthesized via calcination treatment and electrodeposition, coupled with hydrothermal reaction. This composite could appreciably enlarge the electrochemically active surface area of the as-prepared sensor to promote electron transfer and result in the enhanced response signals.With the assistance of differential pulse voltammetry (DPV) and cyclic voltammetry (CV), the electrochemical performance of sensor can be greatly enhanced. Under these optimum conditions, the designed electrochemical sensor was able to sense RT at the lower detection limit (LOD) of 0.69 nM (S/N = 3) with a wider range of 5–500 nM and showed high sensitivity of 1.97 μA. nM−1. cm−2 at room temperature. Additionally, the selective investigation on RT was performed with the related interfering molecules, and the g-C3N4-MWCNTs/Ag/β-CD-MOF/GCE showed decent stability and reproducibility. The real-time application of the modified electrode for RT detection was monitored in both pharmaceutical and serum samples with the satisfactory recovery. Overall, this research contributes to the field of the electroanalytical sensing and offers the potential applications in the drug monitoring.