431. Connectome-Based Predictive Modeling of Psychosis Symptoms in Early and Chronic Psychosis

The symptoms of psychosis-spectrum disorders can cause significant distress and disability. These include positive symptoms (e.g., hallucinations and delusions) and negative symptoms (e.g., memory impairment and disorganized thinking). Early (EP) and chronic (CP) stages of psychosis have predominantly been studied and characterized independently or in comparison to control populations. In this study, we identify biologically-based early (EP, n=107) and chronic (CP, n=123) psychosis symptom networks using connectome-based predictive modeling (CPM) and resting-state functional magnetic resonance imaging. We predicted positive and negative symptoms from the PANSS in both samples. Virtual lesioning analyses highlight the frontoparietal network as important for EP and CP symptom networks. Nevertheless, the specific functional connections used for prediction differ across groups. Finally, group differences compared to healthy controls (n=150) were observed for CP but not EP. These differences broadly overlapped with the symptom model for both EP and CP. Our results encourage using longitudinal studies to track connectivity changes in putative symptom networks during the progression of psychosis. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study did not directly receive any funding. M.F. was supported by the Gruber and Quad Fellowships. Any findings, conclusions, or recommendations expressed in this material are those solely of the authors and do not necessarily reflect those of the funding agencies. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: This study only used open-source human data originally located at the Human Connectome Project Early Psychosis and the Strategic Research Program for Brain Sciences. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes Raw imaging and behavioral data are available through the Human Connectome Project for Early Psychosis (https://nda.nih.gov/general-query.html?q=query=featured-datasets:Connectomes%20Related%20to%20Human%20Disease) and Strategic Research Program for Brain Sciences (https://www.synapse.org/#!Synapse:syn22317078) .