Dual Stress Factors Adaptive Evolution for High EPA Production in Schizochytrium Sp. and Metabolomics Mechanism Analysis
Bioprocess and Biosystems Engineering(2024)
摘要
Eicosapentaenoic acid (EPA) is a vital ɷ-3 polyunsaturated fatty acid (PUFA) for human body with various physiological functions. In this study, we proposed an adaptive evolutionary strategy based on high-temperature and high-oxygen two-factor stress to increase the EPA production capacity of Schizochytrium. High-temperature stress was used to increase EPA yield, and high oxygen was implemented to continuously stimulate cell growth and lipid accumulation. The biomass and EPA production of ALE-D50 reached 35.33 g/L and 1.54 g/L, which were 43.85
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关键词
Schizochytrium sp.,Eicosapentaenoic acid,Adaptive laboratory evolution,Metabolomics
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