Highly anticipated natural diterpenoids as an important source of new drugs in 2013–2023

Chinese Chemical Letters(2024)

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摘要
This review covers the structures of diterpenoids, including chain (72), monocyclic (9), labdane-type (67), clerodane-type (127) abietane-type (716), (ent)-kaurane-type (89), grayanane-type (331), ingenane-type (55), tigliane-type (154), daphnane-type (237), and aconitine-type diterpene alkaloids (265) with rich biological activities reported in 2013–2023. And the drugs in clinical use or under clinical investigation of diterpenoids and leading compounds were summarized.
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关键词
Natural diterpenoids,Structures,Bioactivities,Druggability,Leading compounds,New drugs
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