Figure 3 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Multi-omics biomarkers of combination activity. A, Schematic of biomarker pipeline including molecular features incorporated and analyses performed. Created with BioRender.com. B, Volcano plot of biomarkers from all analyses. Statistically significant associations are colored by analysis type, nonsignificant biomarkers are colored gray. C, Venn diagrams of the biomarkers from different inputs leading to the identification of emergent biomarkers. Note that single-agent biomarkers may be duplicated for the multiple combinations in which the single agent has been screened: the Venn diagram depicts unique single-agent biomarker associations only. D, Significant enriched pathways for emergent biomarkers in each drug combination category based on P_adj values. * 0.05 < P < 0.01, ** 0.01 < P < 0.001, *** P < 0.001. CD, cell death; CS, cell signaling; chemo, chemotherapeutic agents.