Figure 2 from Molecular and Pathologic Characterization of YAP1-Expressing Small Cell Lung Cancer Cell Lines Leads to Reclassification as SMARCA4-Deficient Malignancies

SMARCA4-deficient SCLC cell lines are morphologically and immunophenotypically similar to SMARCA4-UT. A, Outline of the methodology employed for assessing SMARCA4-deficient SCLC cell lines by a panel of five anatomical pathologists. B, Representative H&E images of cell line xenografts diagnosed as high-grade NE carcinoma (SCLC) and other malignant neoplasms (non-SCLC). Scale bar = 100 μm. C, Heatmap of re-evaluated diagnosis of SCLC cell line xenografts (row) and each pathologists’ classification (column). Abbreviations: LCNEC, large cell neuroendocrine cancer; SMARCA4-UT, SMARCA4-deficient undifferentiated tumor; SCLC/LCNEC, combined SCLC and LCNEC components; Other, undifferentiated tumor or small blue round cell tumor.