Effect of Lidocaine-prilocaine Cream on Using CPAP Mask Amongst Patients Undergone PAPtitration Study for Obstructive Sleep Apnea: A Randomized Controlled Trial Study

Despite the high efficacy of using Continuous positive airway pressure (CPAP) in reversing upper airway obstruction in obstructive sleep apnea (OSA), the efficiency of this treatment is limited due to the low adherence. Mask pressure is suggested to play a significant role in adherence. In this study, we intend to investigate the effect of Lidocaine-prilocaine cream CPAP mask on pressure sensation. In this study, 75 patients referred to CPAP titration were divided into three groups. In groups one and two, Lidocaine-prilocaine cream and Petroleum jelly were used respectively. The third group had no intervention. VAS discomfort immediately (VAS0), after 15 min (VAS15), and the next day (VAS all) in three groups were compared. VAS0, VAS15, and VAS all were not significantly different among the three groups (P > 0.05). Among participants with VAS0 above 5, VAS15 was significantly lower in intervention groups than the control group (P < 0.05). This study shows that both Petroleum jelly and Lidocaine-prilocaine cream can be used for decreasing pressure sensation during CPAP titration among patients who suffer excessive facial discomfort immediately after putting on a CPAP mask.