Aqueous Extracts of Cannabis sativa: Cytotoxicity and Effects on Angiogenesis, Oxidative Stress and Nitric Oxide Production

Cannabis sativa has been used in local medicine to manage cancer, ache, inflammation, diabetes, and other conditions. The aqueous extract of Cannabis sativa leaves collected from two geographical locations (South Africa, EC and Lesotho, LS) was assessed for their potential against angiogenesis, nitric oxide (NO) production, oxidative stress and cytotoxicity. The EC extract showed better angiogenesis and vascular endothelial growth factor suppression than the LS extract at 20 and 100 µg/mL. EC and LS displayed their highest NO inhibitory effects (91 and 76