Tracing Embryonic Hematopoiesis Guides Induction of Pluripotent Stem Cells to Hematopoietic Progenitors
Developmental cell(2024)
摘要
In this issue of Developmental Cell, Fowler et al. applied genetic lineage-tracing mouse models to support the notion that artery endothelial cells are the predominant source of hematopoietic stem cells. They leveraged this and developed a method capable of efficiently differentiating human pluripotent stem cells into HLF+HOXA+ hematopoietic progenitors.
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